I have a lot of experience working with both, Magento 1, as all front-end tools like less, grunt and so on.
But now working in Magento2 i have some concerns i've not been able to solve this weekend. I've been searching like crazy. I do hear many other developers experiencing the same.
The bottom line of the issue is. The site is slow. (10sec load times per page is not strange)
I walked through the entire devdocs of magento. But in production mode Magento re-generated the CSS and such. But this taks a huge amount of time. I used Vagrant and Digital ocean server. Even though Digital Ocean is quicker its not useable to develop on.
Whats the best way to proceed?