Patched Magento with SUPEE-5994 and was successful. After clearing cache and clearing and disabling compilation site worked fine.
I then patched with SUPEE-6285 and whilst indicating it was successful in the ssh console i now can not access either the store or admin. The HTTP error log shows the following...
PHP Warning: require_once(/var/www/html/app/Mage.php): failed to open stream: Permission denied in /var/www/html/index.php on line 69
PHP Fatal error: require_once(): Failed opening required '/var/www/html/app/Mage.php' (include_path='.:/usr/share/pear:/usr/share/php') in /var/www/html/index.php on line 69