I have installed vanilla (with sample data) Magento Community edition 2.4.2 on Mac OS with following technology stack however styles are not loaded at all, not even in head block. However I can see all CSS files in pub/static folder when content is deployed. As it can be seen in attached screenshot, there are NO errors in browser console as well.
Web server: Nginx
PHP: 7.4 with fpm
Elastic Search: v7
Mysql: 5.7.32 (Here I agree that on Magento's site Mysql 8 is recommended but with same version on linux, it works as expected.)