I have a site with Magento 2.3.3 version with over 10000 catalog products. For performance purposes which Indexer should set "Update on Save" or "Update On Schedule".
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Update on Save: The index is set to update whenever a change is saved form backend Or from API
Update on Schedule: The index is set to update on schedule according to a cron job. It is recommended set indexers to Update on Schedule.
To Optimize indexing process, I recommend you to check below post as I refer it multiple times: