You can use the salesOrderManagementV1 to add a comment to an order email and send an email:
POST /V1/orders/{id}/comments
POST /V1/orders/{id}/emails
Some details from the code:
<route url="/V1/orders/:id/emails" method="POST">
<service class="Magento\Sales\Api\OrderManagementInterface" method="notify"/>
<resources>
<resource ref="Magento_Sales::sales" />
</resources>
</route>
You can also add a comment in that email:
<route url="/V1/orders/:id/comments" method="POST">
<service class="Magento\Sales\Api\OrderManagementInterface" method="addComment"/>
<resources>
<resource ref="Magento_Sales::sales" />
</resources>
</route>
Digging into the API code:
/**
* Adds a comment to a specified order.
*
* @param int $id The order ID.
* @param \Magento\Sales\Api\Data\OrderStatusHistoryInterface $statusHistory Status history comment.
* @return bool
*/
public function addComment($id, \Magento\Sales\Api\Data\OrderStatusHistoryInterface $statusHistory);
/**
* Emails a user a specified order.
*
* @param int $id The order ID.
* @return bool
*/
public function notify($id);